INFLUENCE OF EXO- AND ENDOGENOUS FACTORS ON THE MORPHOLOGICAL AND FUNCTIONAL STATE OF THE SPLEEN AS AN IMPORTANT MEDICAL AND SOCIAL PROBLEM OF THE HEALTH CARE SYSTEM

Over the past century, since rapid development of mankind as a civilization, state environment and conditions everyday human existence have undergone significant changes. Diseases spleen play an important role in system pathologies internal organs. The is often considered “forgotten organ” among clinicians radiologists. Nevertheless, can be involved variety congenital acquired diseases, which makes it to study influence exogenous endogenous factors on its morphological functional state. aim analyze literature data modern studies published scientific metric databases Scopus, Web Science, Google Scholar English Ukrainian summarize results identify key gaps known data. We found that spleen’s functions are focused systemic circulation, so has no afferent lymphatic vessels. Spleen architectural features been described aging, chronic stress, sleep deprivation, under electromagnetic radiation, radiation exposure, sodium glutamate, nitrite, fluoride. In forensic practice, trauma most common pathology spleen. Changes also occur setting death from anaphylaxis, drowning, sepsis. Autopsy plays toxicological research. clinical diseases usually structure other disease syndromes, but main changes asplenia, splenomegaly, hypersplenism. Thus, sources indicate not only processes immune regulation maintaining body’s homeostasis through participation hematopoiesis response stress. At same time, numerous conducted vulnerability factors, manifested by particular, glutamate nitrite effect spleen, their combined effect, well Ponceau 4R found, indicates relevance studying combination.